Associate Professor of Molecular Genetics, Head of Agricultural Biotechnology Department

My main research interest is studying the molecular pattern of genetic resources and the gene expression profile related to differentially expressed genes in various biological systems.

Biography

Osama Said was born in 1977 as a second child in a normal Egyptian family. He had the opportunity to be influenced by the European culture through his early childhood while his father was doing his abroad study in Germany. This enlightening experience gave him the motivation and passion to look at things differently. So, he has chosen to study Genetics at the Faculty of Agriculture Ain Shams University where he also got his M.Sc. in 2005.  He managed to join the MUST family in September 2005 as a Teaching Assistant. He pursuit his dream of being a remarkable and effective candidate at College of Biotechnology by finishing his PhD study in 2012. He managed to publish several publications through the collaboration with different research groups and was promoted to be an Associate Professor of Molecular Genetics in 2019. Since September 2020 till now he was assigned as the head of the Agricultural Biotechnology department at College of Biotechnology.  His research interest is focused on a broad range of activities related to molecular characterization of Plant or Animal Genetic resources, the understanding of the differential expression of Cancer related genes and its role in cancer progression as well as genome and RNA editing technologies.

Education

• B. Sc. in Genetics, Faculty of Agriculture, Ain Shams University (1999).
• M. Sc. Genetics, Faculty of Agriculture, Ain Shams University (2005). Thesis title: “Genetic characterization of some medicinal plants”.
• Ph.D. Genetics, Faculty of Agriculture, Ain Shams University (2012). Thesis title: “Genetic improvement of some important active ingredients in some medicinal plants”.

Publications

Sabit, A. Farouk, O. Said, Maha Yehia and Aliaa Bishr (2011). Molecular Characterization of Bifidobacteria and Lactobacillus and Their Role in Modulating Immune System and Alleviating Ulcerative Colitis in Mice. Global Journal of Molecular Sciences 6 (1): 09-14.

Sabit, O. A. M. Said, A. F. Shamseldin, Kholoud Elsayed (2011). Molecular Identification of Acinetobacter Isolated from Egyptian Dumpsite as Potential Bacteria to Degrade Malathion. International Journal of Academic Research 3 (4): 84-90.

Hussein Sabit, Hala B. Al-Sharkawy, Mariam Al-Zaidy, Mohamed A. Abdel-Baseer, Nabil S. Awad, Walid N. Al- Mazny, Najla Bint Saud Al-Saud, Moez M. Elsaadani, Mohamed M. M. Ibrahim and Osama A. M. Said. (2014). Small Interference RNA-mediated Down regulation of Survivin Expression in Breast and Hepatocellular Carcinoma Cell Lines. World Journal of Medical Sciences 10 (4): 421-426.

Hussein Sabit, Arwa S. Abdel-Sattar, Shimaa E. Abdel-Ghany, Asmaa M. Abushady, Osama A. M. Said (2015). Cyclophosphamide with Adjuvant Chemotherapeutic Drugs Induces Epigenetic Changes in Hepatocellular Carcinoma Cells. Cancer Biology, 5(4) 26 – 34.

Mohamed M.M. Ibrahim, Hussein H. Sabit, Mohammad A. El-Ghor, Osama A.M. Said, Maye M. Abdulatif, Nouran A. Yousef, Kholod E. Abo-Elkher, Moez M. Elsaadani, Omar S. Abd El-Ghaffar, Abeer E. Mohamed, Doaa A. Yousef, Marihan A. Ahmed, Silvia G. Kamel, Mounir M. Elsafty, Sahar E. Aoda, Najla Bint Saud Al-Saud, Shimaa E. Ibrahimf, Marwa A. AbdElrahman, Nagwa E. Khaleel, and Mokhtar M. Elzawahri (2016). Molecular Genetic Diagnosis and Characterization of Egyptian H5N1 Viral Antigenic Genes. Wulfenia Journal Klagenfurt, Austria, V. 23, No. 1; 33-51.

Hussein Sabit, Mariam B. Samy, Osama A. M. Said, and Mokhtar M. Elzawahri (2016). Procaine Induces Epigenetic Changes in HCT116 Colon Cancer Cells. Genetics Research International, 1-7.

Hussein Sabit, Mostafa Fathy, Shimaa E. Abdel-Ghany, Osama A. M. Said, Mokhtar M. El-Zawahry (2017). Vorinostat Combined with DNA Methyltransferase Inhibitors Epigenetically Controls the Proliferation of Lung Cancer Cells A549. International Journal of Science and Research (IJSR), 855 -860.

Hussein Sabit, Shimaa E. Abdel-Ghany, Osama A. M. Said, Mohamed A. Mostafa, Mokhtar El-Zawahry (2018). Metformin Reshapes the Methylation Profile in Breast and Colorectal Cancer Cells. Asian Pacific Journal of Cancer Prevention. Asian Pac J Cancer Prev, 19 (10), 2991-2999.

Hussein Sabit, Shaimaa Nazir, Shimaa Abdel-Ghany, Osama A. Said, Eman W. Mohammed, Omnia M. Badawy, Ashraf El-zayyat, Amany I. Alqosaibi, Emre Cevik, Huseyin Tombuloglu, Mokhtar Elzawahri (2019). Poly (ADP-ribose) Polymerase Promoter Hypermethylation Predispose Females to Breast Cancer. Asian Pacific Journal of Cancer Biology, 4 (1), 1-5.

Hussein Sabit, Doha Alaa, Nourhan Jamal, Sodfa Tarek, Magda Fouda, Bassant Maher, Abdel-Bary Prince, Shimaa E. Abdel-Ghany, Osama A. M. Said, Abdulrahman Sabry, and Mokhtar El-Zawahry (2019). CRISPR/Cas9-based Editing of CDK4, p107, and TGFβ1 Genes in Human Breast and Lung Cancer Cells. Journal of Biomedical Science. Oncogen 2(3): 15.

Hussein Sabit, Katrine Farag; Shaimaa EAbdel-Ghany; Amany Alqosaibi; Emre Cevik; Huseyin Tombuloglu; Huseyin Bekir Yildiz; Ferhad Serag ElDeen; Osama Said; Mokhtar El-Zawahri (2019). miRNA Profiling in MCF-7 Breast Cancer Cells: Seeking a New Biomarker. Journal of Biomedical Sciences, Vol.8 No.2:3.

Shaimaa Abdel-Ghany, Sara Raslan, Huseyin Tombuloglu, Aly Shamseddin, Emre Cevik, Osama A. Said, Engy F. Madyan, Mehmet Senel, Ayhan Bozkurt, Suriya Rehman& Hussein Sabit (2020). Vorinostat-loaded titanium oxide nanoparticles (anatase) induce G2/M cell cycle arrest in breast cancer cells via PALB2 upregulation. 3 Biotech 10, 407.

Hussein Sabit, Shaimaa Abdel-Ghany, Zamzam Al-Dhafar, Osama A. Said, Jawad Ali Al-Saeed, Yousef Ahmed Alfehaid, Mohamed Aly Osman (2021). Molecular characterization and phylogenetic analysis of Rhynchophorus ferrugineus (Olivier) in Eastern Province, Saudi Arabia, Saudi Journal of Biological Sciences, Volume 28, Issue 10, October 2021, Pages 5621-5630.

Ahmed M. Ramadan, Osama A. M. Said& Asmaa M. Abushady (2021). Salinity stress reveals three types of RNA editing sites in mitochondrial Nad7 gene of wild barley both in silico and in qRT-PCR experiments. Exp. Plant Physiol. https://doi.org/10.1007/s40626-021-00225-x.

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